Abrikossoff tumor of the vulva
How to cite this article: Nair PS, Sudhesan A. Abrikossoff tumor of the vulva. J Skin Sex Transm Dis doi: 10.25259/JSSTD_50_2023.
A 36-year-old female patient presented with no history of pre or extramarital sexual contact and gave the history of a single, asymptomatic, and raised lesion over labia minora of 4 years duration. On examination, a single, well defined, non-tender, non-bleeding, oval, reddish brown, and indurated plaque of size 2 × 1 cm with a smooth surface was present at the junction of the upper one-third and lower two-third of left labia minora [Figure 1]. There was no vaginal discharge or inguinal lymphadenopathy. Viral markers for human immunodeficiency virus, hepatitis B, C, and investigations for other sexually transmitted infections were negative.
An excision biopsy and histopathological examination demonstrated a tumor composed of sheets of large polyhedral cells with eosinophilic granular cytoplasm and small round central basophilic nuclei with distinct cell borders, diagnostic of Abrikossoff tumor [Figure 2]. Abrikossoff tumor (granular cell tumor) is a rare benign peripheral nerve sheath tumor of Schwann cell origin, the usual sites being the tongue, head, neck, and breast, the vulva being a very rare site. The tumors are S-100 positive and periodic acid-schiff positive, staining the cytoplasmic granules, while diastase resistant. Rarely malignant transformation (2%) may occur. Excision margin is the treatment of choice as this tumor can infiltrate deep and recurrences are possible in 2–8%. In our patient, excision was done with a 1 cm margin of normal skin. Recurrent tumors may be treated with radiation and chemotherapy–pazopanib a selective tyrosine kinase inhibitor that blocks tumor growth and inhibits angiogenesis.
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Conflicts of interest
Dr. Pradeep S Nair is on the editorial board of the Journal.
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